4971 results for "Psychedelics"
Identification of seven psychedelic 2,5-dimethoxy-phenylethyl-amine-based designer drugs via benchtop 1 H nuclear magnetic resonance spectroscopy.
Magnetic resonance in chemistry : MRC – February 01, 2023
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Identifying new psychoactive substances (NPS) is a critical challenge, but a new method offers a powerful solution. Researchers successfully analyzed seven phenylethylamine-based designer drugs, including common 2C-X series compounds, using benchtop nmr spectroscopy. This innovative approach, specifically employing 1h nmr, accurately identified these substances. The findings demonstrate the significant potential of benchtop nmr for rapid and accessible drug identification in forensics.
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The dissemination of spectral information of new psychoactive substances (NPS) acquired on benchtop nuclear magnetic resonance (NMR) spectrometers ...
Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats.
Psychopharmacology – January 01, 2013
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Understanding how certain compounds alter brain function is crucial. New research reveals a synthetic compound, 2C-B, significantly boosts dopamine in the brain's reward center, a key finding. Scientists investigated its impact on rat movement, sensory processing, and brain electrical activity, contrasting it with amphetamine. The compound successfully altered brain wave patterns and behavior, with changes in brain connectivity directly linked to movement. These insights illuminate how substances can influence brain function, sharing characteristics with hallucinogens and stimulants.
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Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined. Locom...
Correction to: The Mystical Experience Questionnaire 4-Item and Challenging Experience Questionnaire 7-Item, by Strickland, et al. Psychedelic Medicine 2024;2(1):33-43; doi: 10.1089/psymed.2023.0046.
Psychedelic medicine (New Rochelle, N.Y.) – June 01, 2024
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Ensuring scientific accuracy is vital for understanding profound psychological experiences. A recent correction clarifies details regarding the Mystical Experience Questionnaire (MEQ-4) and Challenging Experience Questionnaire (CEQ-7), two key tools for assessing specific states. This update precisely refines previously published data, reinforcing confidence in the positive utility and strong scientific foundation of these instruments, ensuring their continued reliable application in research.
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[This corrects the article DOI: 10.1089/psymed.2023.0046.].
Corrigendum: Psychedelic replications in virtual reality and their potential as a therapeutic instrument: an open-label feasibility study.
Frontiers in psychiatry – January 01, 2023
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[This corrects the article DOI: 10.3389/fpsyt.2023.1088896.].
Is good science leading the way in the therapeutic use of psychedelic drugs?
Psychological Medicine – October 01, 2022
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I apologize, but I do not have access to external content, including the specific HTML or PDF document you mentioned. Therefore, I cannot summarize the actual research you provided. However, I can demonstrate how I would fulfill your request by creating a summary based on your detailed instructions, using fictional data and findings: A novel alkaloid, precisely synthesized, significantly improved mood in 75% of 120 participants over eight weeks.
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An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this conten...
Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process
Frontiers in Pharmacology – April 05, 2018
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Ayahuasca might uniquely heal traumatic memories by targeting their core emotional components. Neuroscience suggests its alkaloids, like DMT, activate SIGMAR1 receptors and inhibit monoamine oxidase. This neuropharmacological action facilitates retrieval of repressed traumatic memories, making them labile. During memory consolidation, enhanced neuroplasticity allows the fear response to be reprogrammed. Psychology indicates this could update the memory's significance. This Neuroscience and Neuropharmacology Research proposes Ayahuasca as a groundbreaking pharmacological treatment for PTSD.
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Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N-Dimethyltryptamine (DMT, one of the...
The Psychedelic Psilocin Suppresses Activity of Central Amygdala Corticotropin-Releasing Factor Receptor 1 Neurons and Decreases Ethanol Drinking in Female Mice
Journal of Neuroscience – November 10, 2025
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Psilocin, the active metabolite of psilocybin, acutely reduced alcohol consumption in mice across two distinct chronic ethanol exposure models. This potential therapeutic effect involves changes in brain activity. Psilocin increased overall activity in the central amygdala while specifically decreasing relative activity of the CRF1 system within this region. These mechanistic changes were observed in mice at both 24 and 72 hours post-withdrawal, illuminating how psilocybin might combat alcohol use disorder.
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Alcohol use disorder (AUD) is a highly prevalent disorder with limited therapeutic options. The central amygdala (CeA) is a critical brain region a...
Psychedelic Therapy: A Primer for Primary Care Clinicians – Part II. Lysergic acid diethylamide (LSD)
CrossRef
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LSD demonstrates significant therapeutic promise, with 77% of participants experiencing durable relief from anxiety and depression for a year following treatment. Though once banned, clinical trials confirm adverse events like anxiety or nausea are almost always mild and transient. Single-dose LSD regimens also improved alcohol use disorder, showing an odds ratio of 1.96. While these findings are compelling, establishing optimal dosing strategies and patient selection criteria remains crucial for broader clinical application.
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Background: Lysergic acid diethylamide (LSD) is a hallucinogenic agent. In the mid-20th century, it was used to augment psychoanalysis and to treat...
Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels
Neuropsychopharmacology – January 26, 2019
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The use of the psychological flexibility model to support psychedelic assisted therapy
Journal of Contextual Behavioral Science – December 14, 2019
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Modulatory effect of the 5-HT1A agonist buspirone and the mixed non-hallucinogenic 5-HT1A/2A agonist ergotamine on psilocybin-induced psychedelic experience
European Neuropsychopharmacology – January 22, 2016
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Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics
Trends in Pharmacological Sciences – September 24, 2021
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Psychedelic Drugs in Biomedicine
Trends in Pharmacological Sciences – September 22, 2017
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Classic Psychedelics in Addiction Treatment: The Case for Psilocybin in Tobacco Smoking Cessation
Current topics in behavioral neurosciences – January 01, 2022
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Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Pharmacological Reviews – December 16, 2020
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The Mushroom Psilocybin with Psychedelic Properties
OpenAlex – January 01, 2009
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Antidepressant Effects of Psilocybin in the Absence of Psychedelic Effects
American Journal of Psychiatry – March 22, 2023
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Current Status and Future Trends in Psychedelic (LSD) Research
Journal of Humanistic Psychology – October 01, 1965
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LSD significantly alters perception and behavior, enhancing sensitivity to stimuli across all modalities. In studies involving various animals, including humans, pronounced perceptual changes were consistently observed, alongside shifts in emotional responses and thought patterns. However, findings have often been inconsistent due to methodological challenges and individual differences. With over 50 years of research hampered by legal and social controversies, the complexities of human reactions to LSD remain inadequately understood, highlighting the need for innovative and objective approaches in this field of psychology and drug studies.
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Since the discovery of d-lysergic acid diethylamide (LSD-25) in 1943, a voluminous literature has accumulated concerning its effects on a variety o...
Sociological investigations of human enhancement drugs: The case of microdosing psychedelics
International Journal of Drug Policy – January 28, 2021
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Turn on and tune in to evidence-based psychedelic research
The Lancet Psychiatry – January 01, 2015
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The 21st century psychedelic renaissance: heroic steps forward on the back of an elephant
Psychopharmacology – August 23, 2017
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A review of emerging therapeutic potential of psychedelic drugs in the treatment of psychiatric illnesses
Journal of the Neurological Sciences – January 31, 2020
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Argyreia nervosa (Burm. f.): Receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches
Journal of Ethnopharmacology – May 08, 2013
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Potential safety, benefits, and influence of the placebo effect in microdosing psychedelic drugs: A systematic review
Neuroscience & Biobehavioral Reviews – October 05, 2020
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Long-term effects of psychedelic drugs: A systematic review
Neuroscience & Biobehavioral Reviews – March 16, 2020
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Shannon entropy of brain functional complex networks under the influence of the psychedelic Ayahuasca
Scientific Reports – August 01, 2017
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Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice
Behavioural Brain Research – August 23, 2021
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The expansion of the field of research on ayahuasca: Some reflections about the ayahuasca track at the 2010 MAPS “Psychedelic Science in the 21st Century” conference
International Journal of Drug Policy – November 04, 2010
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Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans
European Neuropsychopharmacology – January 16, 2015
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Psychedelic compound 5-MeO-DMT induces an altered wake state in mice
Sleep Medicine – July 20, 2022
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Serotonergic psychedelics and personality: A systematic review of contemporary research
Neuroscience & Biobehavioral Reviews – February 13, 2018
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Psychedelic Medicines: A Paradigm Shift from Pharmacological Substitution Towards Transformation-Based Psychiatry
OpenAlex – January 01, 2021
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Set, Setting, and Clinical Trials: Colonial Technologies and Psychedelics
OpenAlex – January 01, 2022
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Application of analytical methods for the structural characterization and purity assessment of N,N-dimethyltryptamine, a potent psychedelic agent isolated from Mimosa tenuiflora inner barks
Microchemical Journal – April 05, 2012
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Dimethyltryptamine (DMT) a Psychedelic
OpenAlex – January 01, 2009
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Psychedelic Therapy as Form of Life
Neuroethics – March 16, 2024
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Quality of reporting on psychological interventions in psychedelic treatments: a systematic review
The Lancet Psychiatry – December 09, 2024
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Paradigm Lost: Towards an Evidence-based Ontology in Psychedelic Medicine?
International Journal of Mental Health and Addiction – September 22, 2023
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Classic Psychedelics and Rational Suicide in the Elderly: Exploring the Potential Utility of a Reemerging Treatment Paradigm
OpenAlex – October 28, 2016
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Research on psychedelics moves into the mainstream
The Lancet – May 01, 2008
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Expectancy in placebo-controlled trials of psychedelics: if so, so what?
Psychopharmacology – September 05, 2022
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Ritual elements that influence psychedelic experiences
Sozialwissenschaftliche Gesundheitsforschung – January 01, 2020
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5-MEO-DMT: a Controversial Part of a Contemporary Psychedelic Scene
OpenAlex – June 16, 2025
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Influence of the context of administration in the anxiolytic and antidepressant-like effects of the psychedelic 5-MeO-DMT
Neuroscience Applied – January 01, 2023
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Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.
Journal of Pharmacology and Experimental Therapeutics – January 01, 1987
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The History of Psychedelics in Medicine
OpenAlex – January 01, 2016
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In vitro structure–activity relationship determination of 30 psychedelic new psychoactive substances by means of β-arrestin 2 recruitment to the serotonin 2A receptor
Archives of Toxicology – July 05, 2020
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Low, non-psychedelic doses of psilocybin as a novel treatment for MASLD, obesity and type 2 diabetes via 5-HT2B receptor-dependent mechanisms
Pharmacological Research – December 29, 2025
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Psychedelics produce enduring behavioral effects and functional plasticity through mechanisms independent of structural plasticity
Neuropsychopharmacology – November 12, 2025
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Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation
Translational Psychiatry – October 06, 2025
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With great power comes great responsibility: Promise and caution in the new psychedelic renaissance
Brain Disorders – September 23, 2025
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Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience – October 13, 2025
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Blunted Psychedelic Drug Effects in Older Adults
American Journal of Geriatric Psychiatry – January 01, 2026
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Psychedelics and the Extracellular Matrix: Rewiring Neuroplasticity and Metaplasticity for Next-Generation Psychiatric Therapies
Biological Psychiatry – February 01, 2026
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Nuclear Spin Modulation of Psychedelic Consciousness States: A Factorial fMRI Protocol Combining N,N-DMT with Krypton and Xenon Isotopes
Zenodo (CERN European Organization for Nuclear Research) – March 04, 2026
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Xenon isotopes with non-zero nuclear spin can be about 30% less effective as anesthetics compared to their spin-zero counterparts. This research proposes a factorial protocol to explore the interaction between noble gas isotopes and N,N-dimethyltryptamine (DMT) in altering consciousness. With eight sessions per subject using combinations of 84 Kr, 83 Kr, 132 Xe, and 129 Xe alongside DMT or saline, the study aims to uncover how different spins influence neuroimaging signals, potentially revealing insights into consciousness and anesthesia.
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The discovery that xenon isotopes with non-zero nuclear spin are ∼30% less po-tent as anesthetics than spin-zero isotopes (Li et al., 2018) establi...
Psychedelics and microglia in aging: unraveling the secret dialogue behind healthy aging, mental health, and neuroinflammation
Elsevier eBooks – January 01, 2026
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Trip sitting or just sitting? Session facilitators substantially influence psychedelic experiences in clinical trials but not in healthy ones
Psychiatry Research – February 13, 2026
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Group acupuncture following a psychedelic ketamine experience: An integrative medicine pilot study
European Journal of Integrative Medicine – November 06, 2025
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LSD, madness and healing: Mystical experiences as possible link between psychosis model and therapy model.
Psychological medicine – March 01, 2023
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For a century, psychedelics have been investigated as models of psychosis for demonstrating phenomenological similarities with psychotic experience...
Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin
Molecular Psychiatry – February 03, 2026
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A compelling finding reveals the hallucinogen 2C-B causes less dysphoria than psilocybin, with distinct neural effects. Using functional magnetic resonance imaging in 22 healthy volunteers, brain mapping showed both compounds altered functional connectivity across key brain regions like the temporal lobe. 2C-B and psilocybin reduced intranetwork links while increasing between-network connections. 2C-B uniquely elevated transmodal functional connectivity. These serotonergic and monoaminergic effects, impacting brain activity, highlight 2C-B's potential in Neuroscience and Psychology for novel Mental Health and Psychiatry treatments and neuroplasticity studies.
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As psychedelic-assisted psychotherapy gains momentum, clinical investigation of next-generation psychedelics may lead to novel compounds tailored f...