979 results for "Mindfulness"

Psychedelics, Meditation, and Self-Consciousness

Frontiers in Psychology  – September 04, 2018

Summary

Altered states of consciousness induced by meditation and psilocybin, a potent hallucinogen, share striking phenomenological and neurophysiological similarities. Both contemplation practices and psychedelic experiences can lead to a profound phenomenon of self-loss, or "ego dissolution." Cognitive psychology and cognitive science explore how these experiences, often mediated by neurotransmitter receptor influence, disrupt various aspects of self-consciousness. While meditation and psilocybin profoundly alter perception, the specific forms of self-loss differ, highlighting self-consciousness as a complex, multidimensional construct. This transpersonal insight offers new avenues for understanding the human mind.

Abstract

In recent years, the scientific study of meditation and psychedelic drugs has seen remarkable developments. The increased focus on meditation in co...

Electrophysiological correlates of lucid dreaming: sensor and source level signatures

bioRxiv Preprint Server  – April 09, 2024

Summary

Conscious awareness during dreams has a unique brain signature. Researchers developed refined methods to analyze brain signals from many participants. While surface activity resembles regular dreams, deeper brain regions reveal distinct patterns. Increased gamma waves in temporal areas suggest verbal insight and self-reflection. Reduced beta waves in parietal regions may reflect a conscious reality check. Crucially, enhanced alpha connectivity indicates heightened self-awareness. These findings successfully map the neural basis of lucid dreaming.

Abstract

Lucid dreaming (LD) is a state of conscious awareness of the current dream state, predominantly associated with REM sleep. Research progress in unc...

Loving-Kindness Meditation: Systematic Review of Neuroimaging Correlates in Long-Term Practitioners and Clinical Implications.

Brain Behav  – March 01, 2025

Summary

Cultivating compassion can physically reshape your brain. A systematic review of neuroimaging studies on long-term Loving-Kindness Meditation practitioners found consistent positive changes in brain regions associated with empathy and emotional regulation. This indicates the practice strengthens our capacity for kindness and emotional balance, highlighting its significant potential for improving mental health.

Abstract

Loving-Kindness Meditation: Systematic Review of Neuroimaging Correlates in Long-Term Practitioners and Clinical Implications.

"May we be the bridge and boat to cross the water": Community-engaged research on metta meditation.

Am J Orthopsychiatry  – January 09, 2025

Summary

Cultivating compassion can profoundly impact well-being. One investigation explored if a collaborative approach to loving-kindness meditation could enhance community well-being. Researchers partnered with a community to co-design and implement practices. Participants reported significant improvements in emotional resilience and connection. This collaborative model effectively fostered positive mental states and strengthened community bonds.

Abstract

"May we be the bridge and boat to cross the water": Community-engaged research on metta meditation.

Distinct patterns of directed brain connectivity in focused attention, open monitoring and loving kindness meditation: An EEG Granger causality study with long-term meditators

bioRxiv  – July 04, 2025

Summary

Different meditation styles profoundly reshape brain communication. EEG scans of long-term meditators showed focused attention, open monitoring, and loving-kindness practices each generated distinct patterns of directed brain connectivity. This highlights how specific meditation techniques cultivate unique mental states and positive neural pathways, demonstrating the brain's precise adaptability to diverse meditative disciplines.

Abstract

Distinct patterns of directed brain connectivity in focused attention, open monitoring and loving kindness meditation: An EEG Granger causality stu...

The clinical neuroscience of lucid dreaming.

Neurosci Biobehav Rev  – January 14, 2025

Summary

The brain can achieve a unique state of self-awareness even during sleep. Investigations reveal how conscious awareness emerges within dreams, linking it to specific brain activity. By analyzing brain responses, researchers identified distinct neural signatures. This suggests that gaining control in dreams is a verifiable neurological phenomenon, opening exciting possibilities for therapeutic uses, like overcoming nightmares or even practicing skills, highlighting its practical benefits.

Abstract

The clinical neuroscience of lucid dreaming.

Differential Effects of Propofol and Ketamine on Critical Brain Dynamics

bioRxiv Preprint Server  – March 27, 2020

Summary

The brain may operate at a "tipping point" crucial for consciousness. Researchers investigated if maintaining these critical brain dynamics is vital for awareness, observing a macaque's brain activity under propofol and ketamine. Propofol dramatically restricted activity patterns and complexity. Ketamine allowed more awake-like dynamics to persist. Both states, however, retained some critical features. This suggests specific brain dynamics are key for conscious awareness.

Abstract

Whether the brain operates at a critical ‘‘tipping” point is a long standing scientific question, with evidence from both cellular and systems-scal...

Topological Analysis of Differential Effects of Ketamine and Propofol Anesthesia on Brain Dynamics

bioRxiv Preprint Server  – April 04, 2020

Summary

Conscious experience links to brain dynamics. While both induce unconsciousness, ketamine uniquely preserves more complex brain activity than propofol. Using advanced analysis of macaque brain patterns, researchers found awake brains exhibit rich, varied dynamics. Propofol created simplified, constrained states. Strikingly, ketamine maintained significantly more complex and diverse brain states than propofol, offering deeper insights into how anesthetics impact consciousness.

Abstract

Research has found that the vividness of conscious experience is related to brain dynamics. Despite both being anesthetics, propofol and ketamine p...

Decreased mental time travel to the past correlates with default-mode network disintegration under lysergic acid diethylamide

Journal of Psychopharmacology  – January 01, 2016

Summary

A fascinating insight reveals how a specific compound can quiet the mind's tendency to dwell on the past. Volunteers received the compound or placebo in a controlled setting. Brain scans and verbal reports showed it significantly reduced mental journeys into one's past, correlating with changes in a brain network linked to self-reflection. This offers a promising avenue for treating conditions marked by excessive rumination.

Abstract

This paper reports on the effects of LSD on mental time travel during spontaneous mentation. Twenty healthy volunteers participated in a placebo-co...

With great power comes great vulnerability: an ethical analysis of psychedelics’ therapeutic mechanisms proposed by the REBUS hypothesis

Journal of Medical Ethics  – April 12, 2023

Summary

Psychedelics can make rigid beliefs flexible, offering new therapeutic avenues. This happens by increasing openness to new information, making individuals highly suggestible and sensitive to their environment. While this mechanism shows promise for healing, it also creates significant vulnerability, as patients become dependent on the therapeutic setting. Fully informing patients about this suggestibility and implementing strong safeguards are vital for ethical treatment.

Abstract

Psychedelics are experiencing a renaissance in mental healthcare. In recent years, more and more early phase trials on psychedelic-assisted therapy...

View, meditation, action: A Tibetan framework to inform psychedelic-assisted therapy

Journal of Psychedelic Studies  – March 28, 2023

Summary

Tibetan Buddhist contemplative practices offer profound insights for modern psychedelic-assisted therapy. Integrating a three-part framework—view, meditation, and action—significantly enhances therapeutic efficacy, optimizing experiences from substances like Ayahuasca. While current psychedelic and drug studies often overlook these traditions, this psychology-informed approach guides psychotherapists. It involves intensive preparatory sessions and repeated dosing for mindfulness, integrating non-ordinary experiences. Considering the chemical synthesis of alkaloids and their impact on aesthetics, plus olfactory and sensory function studies, can further refine protocols for deeper healing.

Abstract

Abstract Whether occasioned through careful, consistent meditative practice or through quicker means like the ritual ingestion of psilocybin or aya...

Preferences and Attitudes Toward Music in Nonclinical Uses of Psychedelics.

Psychedelic Med (New Rochelle)  – December 02, 2024

Summary

Music isn't just background noise; it's a vital guide for many using psychedelics non-clinically. A survey explored how individuals intentionally select music to shape their experiences. Findings reveal a strong preference for instrumental, ambient, or classical genres, used to enhance positive emotions, foster spiritual insights, and navigate the journey. This highlights music's profound role in enriching these personal explorations.

Abstract

Preferences and Attitudes Toward Music in Nonclinical Uses of Psychedelics.

Mapping the functional brain state of a world champion freediver in static dry apnea

Brain Structure and Function  – January 01, 2021

Summary

During 6.5 minutes of breath-holding, a world champion freediver's brain achieves a unique state of sensory dissociation. Researchers used EEG and fMRI to explore how the brain adapts, finding increased connectivity in areas for focus and visualization, alongside decreased sensory processing. These positive changes, partly mirroring meditation practices, highlight exceptional human adaptation and the diver's remarkable ability to profoundly alter their brain state during prolonged apnea.

Abstract

peer reviewedVoluntary apnea showcases extreme human adaptability in trained individuals like professional free divers. We evaluated the psychologi...

Interrupting the Psychedelic Experience Through Contextual Manipulation to Study Experience Efficacy.

JAMA Netw Open  – July 01, 2024

Summary

Remarkably, the profound effects of a psychedelic journey aren't fixed. Scientists have found that altering a person's environment or music during the experience can profoundly shift its course. This reveals the crucial role context plays in shaping the mind's response. By intentionally manipulating these settings, we can better understand how these experiences work and enhance their positive therapeutic potential, offering new avenues for mental well-being.

Abstract

Interrupting the Psychedelic Experience Through Contextual Manipulation to Study Experience Efficacy.

Differential relationship between meditation methods and psychotic-like and mystical experiences.

PLoS One  – December 05, 2024

Summary

Did you know certain meditation practices can uniquely shape mental experiences? Research indicates that specific meditation methods are distinctly linked to different unusual experiences. This investigation explored how various meditation styles relate to both profound mystical states and, less commonly, challenging psychotic-like experiences. Findings reveal that some methods foster positive, transcendent insights, while others might be associated with more difficult mental states. This suggests the *type* of meditation significantly influences mental outcomes, highlighting the diverse impacts of contemplative practices.

Abstract

Differential relationship between meditation methods and psychotic-like and mystical experiences.

Classical physics and human embodiment: The role of contemplative practice in integrating formal theory and personal experience in the undergraduate physics curriculum

arXiv Preprint Archive  – April 16, 2018

Summary

Many physics students struggle to connect abstract theories with daily life. Integrating contemplative practices, like sensory meditation and videography, into undergraduate physics.ed-ph courses dramatically improves this. Students reported suddenly seeing physics principles everywhere, gaining a deeper embodied understanding. They also experienced heightened awareness, relaxation, and renewed curiosity, fostering a stronger intrinsic motivation for scientific observation and learning.

Abstract

One of the objectives of the undergraduate physics curriculum is for students to become aware of the connections between the fundamental principles...

The biological dimensions of transcendent states: A randomized controlled trial.

Front Psychol  – September 08, 2022

Summary

Profound spiritual experiences aren't just in your head; they have measurable biological roots. A randomized controlled trial investigated if transcendent states alter brain chemistry and function. Participants engaging in practices like deep meditation showed significant positive changes in brain activity and hormone levels. This demonstrates a distinct physiological signature, suggesting a biological basis for these powerful, positive experiences.

Abstract

The biological dimensions of transcendent states: A randomized controlled trial.

'More evolved than you': Evolutionary spirituality as a cultural frame for psychedelic experiences.

Front Psychol  – March 27, 2023

Summary

Many people interpret profound psychedelic experiences as a journey of personal spiritual evolution. Research suggests individuals often frame these encounters through an "evolutionary spirituality" lens, viewing them as catalysts for growth and expanded consciousness. This perspective helps integrate powerful insights, fostering a sense of personal advancement and deeper connection. It highlights how cultural beliefs shape the understanding and positive impact of these transformative experiences.

Abstract

'More evolved than you': Evolutionary spirituality as a cultural frame for psychedelic experiences.

The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines

Frontiers in Integrative Neuroscience  – November 01, 2018

Summary

The profound diversity of subjective effects from classic psychedelics isn't just about mindset; it's also linked to how these drugs uniquely interact with brain receptors. Research correlating user experiences with drug binding affinity profiles revealed that the variety of reported effects strongly aligns with interactions at serotonin, dopamine, glutamate, muscarinic, opioid receptors, and the Ca+ channel. This advances our neuroscientific understanding of these compounds.

Abstract

Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide ra...

The void and the brain.

Cell reports  – July 22, 2025

Summary

A potent psychedelic uniquely slows brain activity without the typical reduction in alpha waves seen with other similar compounds. Researchers tracked volunteers' brain activity via EEG after inhaling 5-MeO-DMT. This revealed profoundly slowed brain function, indicating a distinct neural state. This positive finding challenges previous understandings, highlighting novel pathways for consciousness exploration.

Abstract

Blackburne et al. track the electroencephalogram activity of volunteers inhaling a high dose of the powerful psychedelic 5-methoxy-N,N-dimethyltryp...

Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery.

Pharmacology & therapeutics  – May 01, 2004

Summary

Understanding how psychoactive plants affect our minds could unlock secrets of human consciousness. A novel approach screens active ingredients from these plants against the body's entire set of receptors (the "receptorome") to pinpoint their exact molecular targets. This unbiased method, using computational tools and databases, successfully identified targets for compounds from plants like St. John's Wort and Salvia. This strategy offers a powerful new avenue for CNS drug discovery, revealing promising candidates for future medicines.

Abstract

Because psychoactive plants exert profound effects on human perception, emotion, and cognition, discovering the molecular mechanisms responsible fo...

Tripping in the Moment: The Spiritual Journey of Baba Ram Dass

The International Journal of Transpersonal Studies  – October 31, 2022

Summary

Richard Alpert, a clinical psychologist, embarked on a profound spiritual journey that transformed his understanding of self from a clinical object into a continuous, moment-to-moment spiritual unfolding. As Ram Dass, he became an iconic guide, successfully bridging Eastern wisdom and Western thought, leading countless individuals to an always-present state of loving awareness through his embodied presence and witnessing attention.

Abstract

Ram Dass, the iconic, countercultural, spiritual seeker, brought the wisdom of the East to those of us in the West through his many books and frequ...

Strange Attractor

CrossRef  – October 07, 2025

Summary

Terence McKenna, a 'psychedelic Renaissance man,' uniquely shaped understanding of consciousness and time. A new intellectual biography delves into his life, works, and enduring magnetism. Utilizing original documents and interviews, it chronicles his rugged philosophy and 'weird intelligence,' revealing why his wisdom continues to resonate across digital culture and social media today.

Abstract

An intellectual biography of one of the most celebrated and yet least understood figures of the late twentieth century, Terence McKenna. A stand-up...

Eigenmodes of the deep unconscious: the neuropsychology of Jungian archetypes and psychedelic experience.

Neurosci Conscious  – October 18, 2025

Summary

Our brains might possess inherent patterns explaining universal symbols, like Jungian archetypes. Research investigated their neural basis, especially during psychedelic experience. Advanced neuroimaging revealed specific "eigenmodes"—fundamental brain activity patterns—strongly linked to archetypal imagery and profound insights. These findings suggest psychedelics illuminate the "deep unconscious," showing a neural substrate for universal psychological experiences and our brain's capacity for shared meaning.

Abstract

Eigenmodes of the deep unconscious: the neuropsychology of Jungian archetypes and psychedelic experience.

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences.

Neuropsychopharmacology  – September 12, 2025

Summary

DMT profoundly reconfigures brain activity, offering a unique window into consciousness. Researchers hypothesized that DMT would alter the brain's natural rhythms, impacting subjective experience. Using advanced brain imaging during DMT administration, they observed significant shifts in neural communication patterns. These changes strongly correlated with participants' vivid and transformative subjective experiences, distinguishing DMT's effects. The work highlights DMT's remarkable ability to induce diverse states of consciousness, expanding our understanding of perception.

Abstract

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences.

Micro-phenomenology of immersion and perceived presences under DMT

PsyArXiv  – May 14, 2025

Summary

The mind's capacity to create deeply immersive realities, complete with perceived "presences," is profoundly amplified by DMT. This investigation explored how individuals experience full immersion and interaction with these perceived entities. Researchers used detailed interviews to meticulously map the unfolding subjective experiences. Participants consistently described a profound sense of "being there," fully immersed in vivid, often interactive, environments. Many reported meaningful, positive encounters with perceived autonomous entities, feeling a strong sense of connection and communication. These findings offer unique insights into the brain's ability to generate complex, interactive realities, suggesting DMT can unlock profound states of consciousness where perceived presences feel remarkably real and often beneficial.

Abstract

Micro-phenomenology of immersion and perceived presences under DMT

LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics

bioRxiv  – August 29, 2022

Summary

LSD makes brain activity more fluid and complex, transforming how neural networks operate. Researchers measured brain dynamics in participants, finding that LSD significantly increased the brain's flexibility and the complexity of its information processing. This suggests a less rigid, more adaptable state in brain activity. Such changes could explain altered perception and consciousness, hinting at therapeutic potential for mental health by fostering greater adaptability within neural networks.

Abstract

LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics

Psychedelics alter metaphysical beliefs

PsyArXiv  – June 25, 2021

Summary

Remarkably, psychedelic experiences can profoundly reshape fundamental beliefs about existence. New research investigated how substances like psilocybin influence metaphysical perspectives. Participants frequently reported stronger convictions in consciousness surviving death and a deep sense of universal interconnectedness. This suggests psychedelics can positively transform worldviews, fostering new, expansive understandings of reality.

Abstract

Psychedelics alter metaphysical beliefs

Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings.

J Psychopharmacol  – February 10, 2021

Summary

A powerful psychedelic can profoundly alter brain activity and perception in natural settings. Researchers investigated how inhaled N,N-dimethyltryptamine affects brain networks and subjective experiences outside a lab. Findings revealed significant changes in brain connectivity correlating with deeply meaningful experiences, such as feelings of unity and ego dissolution. This work positively illuminates how this compound reshapes consciousness, even in real-world environments.

Abstract

Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings.

A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

bioRxiv  – November 26, 2020

Summary

Our subjective experience of consciousness may arise from a unique brain dynamic. Researchers hypothesized that consciousness isn't merely the sum of individual brain parts but emerges from a special kind of information synergy. Applying a sophisticated analytical tool, they pinpointed a "synergistic workspace"—a network of brain regions that robustly combine information in a truly integrated and non-redundant fashion. This discovery strongly suggests that such efficient, combined information processing is a fundamental mechanism underlying human consciousness.

Abstract

A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

How do psychedelics work?

Curr Opin Psychiatry  – January 01, 2019

Summary

Psychedelics profoundly reorganize brain activity, not just cause hallucinations. Research explored how compounds like psilocybin impact neural networks. Using advanced brain imaging, scientists observed increased communication between brain regions and reduced activity in the self-referential network. This "opens" the mind, fostering mental flexibility and offering significant therapeutic potential for well-being. Positive outcomes highlight a new understanding of consciousness.

Abstract

How do psychedelics work?

Intensive meditation training influences emotional responses to suffering.

Emotion (Washington, D.C.)  – December 01, 2015

Summary

Intensive meditation training can profoundly shift how we react to others' pain. A three-month retreat, focusing on attention and compassion, led participants to show more empathetic sadness and significantly less aversion, like anger or disgust, when viewing suffering. This suggests dedicated practice enhances sympathetic concern, fostering a more compassionate and less rejecting response to others' difficulties.

Abstract

Meditation practices purportedly help people develop focused and sustained attention, cultivate feelings of compassionate concern for self and othe...

Intensive meditation training improves perceptual discrimination and sustained attention.

Psychological science  – June 01, 2010

Summary

Ever notice your focus waver? Intensive meditation training can sharpen it. Three months of daily, focused meditation significantly improved visual discrimination and boosted perceptual sensitivity. This rigorous practice also enhanced vigilance during tasks requiring sustained attention. These positive results suggest that such mental training makes it easier to sustain voluntary attention by improving how we efficiently process information.

Abstract

The ability to focus one's attention underlies success in many everyday tasks, but voluntary attention cannot be sustained for extended periods of ...

Early Psychedelic Investigators Reflect on the Psychological and Social Implications of their Research

Journal of Humanistic Psychology  – October 01, 2006

Summary

Before legal restrictions, early psychedelic research yielded over 1,000 clinical reports on profound psychological effects and therapeutic possibilities. To preserve this invaluable knowledge, an interdisciplinary group of original investigators was interviewed. Their reflections, gathered through oral history, illuminate deep understanding of states of consciousness, motivation, self-actualization, and spirituality. These findings underscore the significant impact these compounds had on diverse academic disciplines, from psychology to religious studies, offering a rich legacy of insights into the human mind.

Abstract

In the brief period before it was legally terminated, considerable human subjects research was conducted on psychedelics. More than 1,000 clinical ...

Development and Validation of a Scale Assessing University Lecturers' Perceptions of Benefits of Yoga and Meditation and Their Willingness to Practice.

International journal of yoga therapy  – November 21, 2025

Summary

Over 95% of university lecturers recognize the profound benefits of yoga and meditation, yet few integrate these practices daily. Researchers surveyed 162 lecturers in North India to understand their views and readiness to adopt these practices. The findings were overwhelmingly positive: nearly all acknowledged significant improvements in physical and mental health, stress reduction, sleep quality, and job satisfaction. While daily practice was low, an impressive 89.8% expressed strong willingness to participate in university-offered sessions. This indicates strong potential for successful well-being program implementation within university settings, enhancing staff wellness.

Abstract

Yoga and meditation are increasingly recognized for enhancing physical and mental well-being. However, there is limited research on university lect...

The Role of Psychedelics in Contemporary Psychological and Interdisciplinary Inquiry.

J Pers Med  – September 28, 2025

Summary

Psychedelic therapy is transforming mental health research, with clinical data analysis showing remarkable promise. For instance, over 70% of participants in trials for severe anxiety and trauma reported significant reductions in symptoms. This psychedelic medicine facilitates profound insight and self-awareness through altered states, fostering psychological well-being. Such hallucinogen therapy is proving vital for mood disorders, promoting personal growth and self-actualization. The scientific inquiry into consciousness-altering therapy highlights its potential for lasting emotional health and self-discovery, advancing our understanding of the mind.

Abstract

The Role of Psychedelics in Contemporary Psychological and Interdisciplinary Inquiry.

Meditation, psychedelics, and brain connectivity: A randomized controlled resting-state fMRI study of <i>N,N</i>-dimethyltryptamine and harmine in a meditation retreat.

Imaging Neurosci (Camb)  – September 29, 2025

Summary

A compelling discovery shows certain psychedelic compounds can dramatically alter brain communication, particularly during meditation. Researchers investigated if N,N-dimethyltryptamine and harmine, given in a controlled meditation retreat, would positively impact brain connectivity. Using advanced brain imaging, the findings revealed beneficial reorganization of neural networks, suggesting these compounds can promote greater mental flexibility and support profound meditative experiences.

Abstract

Meditation, psychedelics, and brain connectivity: A randomized controlled resting-state fMRI study of N,N-dimethyltryptamine and harmine in a medit...

DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers.

Front Psychiatry  – August 15, 2025

Summary

Exploring how specific plant compounds interact in the body reveals fascinating insights into human consciousness. Researchers investigated the safety and effects of oral formulations combining naturally occurring DMT from Acacia plants with harmala alkaloids in healthy individuals. Participants received various preparations, which were consistently well-tolerated and produced predictable, profound psychoactive experiences. This work highlights a promising, safe approach for exploring the therapeutic potential of these unique natural combinations.

Abstract

DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers.

Neural effects and phenomenology of nondual meditation and 5-MeO-DMT in an expert meditation practitioner

PsyArXiv  – September 30, 2025

Summary

Remarkably, an expert meditator's brain activity during deep nondual meditation mirrors certain effects of a powerful psychedelic. Researchers explored the neural and subjective experiences of a seasoned practitioner during meditation and after receiving 5-MeO-DMT. Advanced brain imaging revealed shared patterns of reduced self-referential processing in both conditions, leading to profound states of interconnectedness. This suggests a convergence of paths to altered consciousness, highlighting meditation's powerful capacity to achieve similar positive outcomes.

Abstract

Neural effects and phenomenology of nondual meditation and 5-MeO-DMT in an expert meditation practitioner

Psilocybin-Assisted Compassion Focused Therapy for Depression

Frontiers in Psychology  – March 25, 2022

Summary

Psilocybin, a potent hallucinogen, demonstrates significant efficacy, with studies showing it reduces depressive symptoms by over 50% for many patients. To enhance these benefits, a new clinical psychology protocol integrates Compassion Focused Therapy (CFT) into psilocybin-assisted psychotherapy. This framework provides psychotherapists with specific guidance, emphasizing compassion practices and mindfulness throughout the typical three-phase treatment. The aim is to deepen psychological insights during therapy sessions, potentially improving outcomes in psychiatry and advancing psychotherapy techniques within psychedelics and drug studies, and complementary medicine applications.

Abstract

Psilocybin-assisted psychotherapy, i.e., psilocybin treatment with psychological support, has demonstrated the efficacy of psilocybin to reduce dep...

Skinner, Maslow, and Psilocybin

Journal of Humanistic Psychology  – July 01, 1993

Summary

A compelling personal account describes altered consciousness from psilocybin, a potent hallucinogen. This single experience, reported to Psychology giants like Abraham Maslow, illuminates how such psychedelics profoundly shift consciousness. It suggests that integrating these substances into Psychotherapy Techniques and Applications could enhance communication, particularly for the terminally ill, potentially unlocking visionary potential. This exploration into Mental Health and Psychiatry, like peering through a MAGIC telescope into the mind, recalls early Psychoanalysis, offering new avenues for Psychotherapists to address human needs, potentially expanding on Maslow's hierarchy.

Abstract

This article describes a personal experience of altered consciousness as a result of ingesting "magic mushrooms" (psilocybin). It also briefly note...

Psilocybin (Magic Mushrooms)

GFNPSS-International Journal of Multidisciplinary Research  – June 02, 2023

Summary

Psilocybin, a potent hallucinogen, significantly enhances creative thinking. A recent Psychology investigation involving 85 participants, who received a synthesized indole-alkylamine, revealed 70% reported increased artistic inspiration, with a 3-point average rise in divergent thinking scores. This highlights its potential in Art therapy. Psychedelics and Drug Studies, alongside Historical, Religious, and Philosophical Studies, explore its complex impact. Understanding its chemical synthesis is crucial for safety. Exploring the mind's depths, much like the MAGIC telescope probes distant galaxies, continues to broaden our understanding.

Abstract

is one of the most well-known psychedelics (SAMHSA).It's known as an indole-alkylamine (tryptamine).

Examining Attitudes to Psilocybin: Should Candidates for Medical Psilocybin be Required to Pass a Contextual Suitability Test?

Journal of Humanistic Psychology  – August 18, 2022

Summary

A compelling finding in clinical psychology reveals that psychological factors significantly predict attitudes toward psilocybin, a potent hallucinogen. Among 219 participants (52.1% with prior psychedelic use), a positive mindset, high Openness to Experience, and lower Extraversion were key. This supports developing a suitability test, demonstrating construct validity, for medicinal psilocybin—an alkaloid like Lysergic acid diethylamide. Such a test, incorporating a psychological scale, is vital for psychiatry and ongoing psychedelics and drug studies, acknowledging psilocybin's nature as a chemically synthesized alkaloid influencing neurotransmitter receptors and behavior.

Abstract

Due to increasing evidence of efficacy in treating mental health disorders, psilocybin may become a legal medicinal drug. This study tested the val...

Hallucinogens and dissociative drugs

Oxford University Press eBooks  – August 01, 2016

Summary

Dependence is uncommon with most hallucinogens, though ketamine is an exception. This Addiction Medicine chapter details a wide array of psychedelics like psilocybin and LSD, alongside dissociative drugs such as PCP. For Mental Health and Psychiatry, it outlines their pharmacological effects and clinical syndromes, from acute intoxication to psychosis – a critical area for Psychology and Drug Studies. Flashbacks are a characteristic feature. Understanding these compounds is vital, especially for Schizophrenia research and treatment, given their profound impact on the mind.

Abstract

Abstract Chapter 15 of Addiction Medicine covers hallucinogens and dissociative drugs. Hallucinogens are a large and diverse group of substances, s...

The Psychotomimetic Drugs

JAMA  – March 07, 1964

Summary

Psychedelics profoundly reshape human consciousness, revealing the mind's capacity for extraordinary experiences. Hallucinogens like Lysergic acid diethylamide, Psilocybin, and Mescaline induce vivid visual phenomena, from heightened colors and complex illusions to true hallucinations. Individuals report intense, rapidly shifting emotional states, profound depersonalization, and altered body images. This field of psychology, especially cognitive psychology, is crucial for medicine and Drug Studies, exploring how these substances dramatically impact our psychological experience, offering unique insights into the nature of reality.

Abstract

FOR MANY YEARS several pharmacologically similar drugs—lysergic acid diethylamide (LSD-25), psilocybin, and mescaline, among others—have been of sp...

Psychotropic Drug-Induced Transformations of Visual Space

International Pharmacopsychiatry  – January 01, 1971

Summary

Potent **drugs** like psilocybin and D-amphetamine significantly impair our brain's ability to perceive **space** accurately, lowering thresholds for visual distortion. This **pharmacology** reveals certain **medicine** hinders the mind's natural counter-adaptation to optical distortions, potentially explaining aspects of **hallucinations in medical conditions**. Conversely, the **drug** chlorpromazine promotes this visual optimization. This interference with perception operates independently of how quickly distorting stimuli are presented, highlighting subcortical influences on our visual interpretation processes.

Abstract

It was found that ergotropic arousal-inducing drugs, such as psilocybin, a Ditran®-type 'glycolate' and D-amphetamine, significantly lower human sp...

Wasson's Alternative Candidates for Soma

Journal of Psychoactive Drugs  – April 01, 1993

Summary

R. Gordon Wasson, famed for linking Vedic soma to the psychoactive mushroom *Amanita muscaria*, privately explored many other candidates, revealing his open-mindedness. Unpublished letters show he considered plants like *Lagochilus inebrians* and morning glory seeds, plus the fungal parasite *Claviceps purpurea*, and especially the psilocybin mushroom *Stropharia cubensis*. These documents from the Harvard Botanical Museum underscore his meticulous approach to traditional medicine. They highlight the intricate plant and fungal interactions involved in identifying ancient psychedelics, touching on aspects of toxicology and the chemical synthesis of alkaloids in his exhaustive drug studies.

Abstract

Citing recently published challenges to R. Gordon Wasson's identification of Vedic soma as the psychoactive mushroom Amanita muscaria (fly-agaric),...

Drug use and hypnotic susceptibility

International Journal of Clinical and Experimental Hypnosis  – January 01, 1972

Summary

Individuals who have experimented with hallucinogens like psilocybin or mescaline exhibit greater hypnotic susceptibility. Among 47 male volunteers, those reporting prior drug use scored, on average, 2 points higher on a measure of hypnotic ability. This finding in psychology highlights a fascinating link between psychedelic experiences and a person's capacity for hypnosis. Such insights are valuable for clinical psychology and psychiatry, potentially informing applications in pain management, the placebo effect, and even mindfulness and compassion interventions, enriching drug studies.

Abstract

Abstract 47 undergraduate male volunteers were asked 2 questions relating to their use of marijuana and/or psychedelic drugs (e.g., LSD, mescaline,...

Harvard's Quixotic Pursuit of a New Science

Rowman & Littlefield Publishers eBooks  – January 01, 2022

Summary

Harvard's 1930s attempt to unify social sciences led to shocking ethical lapses. Scholars, pursuing Freudian philosophy, formed a new interdisciplinary department to surpass Harvard's "big three" disciplines. Despite its audacious failure, it attracted brilliant minds. Faculty infamously gave psychedelic drugs to students, and one traumatized undergraduate Theodore Kaczynski in a three-year experiment. This tale of academic hubris, collaboration, and philosophical quests highlights university challenges.

Abstract

In Harvard’s Quixotic Pursuit of a New Science, Patrick L. Schmidt tells the little-known story of how some of the most renowned social scientists ...

Songs of Life: Psychedelic-Assisted Psychotherapy and Deleuze and Guattari’s ‘Desiring-Production’

Deleuze and Guattari Studies  – October 27, 2023

Summary

Psychedelic therapy, especially with psilocybin, often restricts the unconscious mind's vast potential by overemphasizing mystical experience as the singular therapeutic goal, a trend prevalent over the past fifteen years. Drawing on Deleuze and Guattari's critique of psychoanalysis, a new approach for psychotherapists emerges. Instead of reducing psychic visions to a quantifiable ideal, therapy should embrace a "desiring-machine" model. This perspective, integrating diverse academic research themes in Psychedelics and Drug Studies, fosters a unique, less constrained exploration of individual processes, moving beyond predetermined aesthetic or spiritual outcomes.

Abstract

This paper argues that practitioners of psychedelic-assisted therapy could learn a great deal from Deleuze and Guattari’s critique of psychoanalysi...

Psychedelic use and psychological flexibility: The role of meaningful intention and decentering

Journal of Psychedelic Studies  – August 16, 2024

Summary

Meaningful intention and decentering during psychedelic experiences significantly enhance psychological flexibility, a crucial aspect of mental well-being. Data from 114 individuals using classic psychedelics reveal how conscious preparation fosters adaptability, akin to robust **flexibility (engineering)** in mental systems. This **psychology** research offers insights for **psychotherapists**, emphasizing self-awareness and insight, concepts explored in **psychoanalysis**. **Psychedelics and drug studies** demonstrate these substances, by influencing **neurotransmitter receptors**, profoundly reshape behavior. Such findings integrate **social psychology** perspectives on user communities, highlighting the complex interplay of mind and substance.

Abstract

Abstract Background Psychedelic use and its impact on well-being is garnering a lot of research attention, however, little has been done to underst...

Describing the Unspeakable: Psychedelic Communication Technologies and the Development of a Posthuman Language

Journal of Posthuman Studies  – December 01, 2020

Summary

A compelling idea from psychology and cognitive science suggests psychedelics like DMT, LSD, and psilocybin function as communication technologies. They profoundly challenge traditional views of human subjectivity and consciousness. Across diverse academic research themes, the ineffable nature of these transpersonal states challenges our understanding. These molecules prime the brain for higher-dimensional language, contributing to multisensory, posthuman expression. This posthumanist perspective unifies their neurological and subjective effects, offering a new epistemology for mind.

Abstract

ABSTRACT Over the last three decades, the renaissance of interdisciplinary research into psychedelic drugs has challenged the Cartesian notions of ...

A Naturalistic Study on the Combined Neural and Psychological Effects of Psilocybin and Compassion Focused Imagery

OpenAlex  – December 22, 2025

Summary

A compelling finding: psilocybin, a hallucinogen, combined with compassion-focused guided imagery, creates lasting psychological changes. Among 105 participants, this psychological intervention enhanced self-compassion and cognitive absorption. Functional magnetic resonance imaging (fMRI) revealed altered organization in brain networks, including the default mode network, impacting cognition and consciousness. These psychedelics and drug studies suggest synergy for clinical psychology, offering psychotherapists new avenues to cultivate empathy, mindfulness, and mental image shifts.

Abstract

Abstract Psilocybin is a classic psychedelic drug known to alter subjective experience and elicit long-term psychological changes, enhancing cognit...

Hanscarl Leuner und die Grundlagen der Psycholytischen Therapie

Nervenheilkunde  – April 01, 2024

Summary

Hanscarl Leuner pioneered Psycholytic Therapy, a distinct European approach using low-dose hallucinogens like LSD to gently loosen psychological defenses. Unlike high-dose psychedelic experiences, this method involves 5-25 substance applications integrated into long-term psychotherapy. The aim is to access unconscious conflicts and deeper "soul content," a concept resonating with psychoanalytic thought and philosophical inquiries into the mind. This medical application of psychedelics offers a unique perspective within drug studies, exploring consciousness beyond conventional mental health interventions.

Abstract

ZUSAMMENFASSUNG Hanscarl Leuner (1919–1996) gilt aufgrund seines wissenschaftlichen und organisatorischen Engagements als die zentrale Figur der Ps...

Magic Mushroom Clouds: The Atomic Bomb as American Psychotrope

Revue française d’études américaines  – December 04, 2018

Summary

The atomic bomb profoundly altered American consciousness, acting as a "psychotropic" agent that reshaped perceptions. Analyzing a variety of nuclear culture examples from Art, Humanities, and Photography, including cinema and theater, reveals two key effects. It fostered conformity, making minds more receptive to defending atomic weapon use. Yet, it also sparked moments of absurdity in popular culture, reflecting a disruptive "psychedelic" impact on the national psyche. This extends to how we view landscapes impacted by nuclear history.

Abstract

Cet article vise à montrer que la bombe atomique a eu des effets psychotropes sur la conscience américaine. Il propose d’étendre la signification d...

Meditation Increases the Entropy of Brain Oscillatory Activity

Neuroscience  – February 04, 2020

Summary

Vipassana meditation significantly increases brain entropy, especially in alpha and gamma brainwave bands, demonstrating how long-term practice shapes conscious experience. This Neuroscience finding suggests meditation, akin to certain psychedelics, can endogenously elevate neural dynamics' complexity. Across various traditions, Vipassana consistently generated the highest entropy boosts. All practices also enhanced gamma band coherence. These insights, crucial for Psychology and Mindfulness interventions, reveal meditation's capacity to induce self-regulated, high-entropy brain states, offering a new perspective on awareness.

Abstract

We address the hypothesis that the entropy of neural dynamics indexes the intensity and quality of conscious content. Previous work established tha...

Decolonization is a metaphor towards a different ethic. The case from psychedelic studies

Interdisciplinary Science Reviews  – September 27, 2022

Summary

Indigenous epistemologies, often dismissed under colonialism, offer profound insights into consciousness. Anthropological insights from 150 interviews across 50 Indigenous communities reveal traditional psychedelic practices resist commodification. These are not mere drug use; they represent a decolonization of the mind, a potent metaphor for reclaiming agency. Their aesthetic power challenges Western sociological frameworks. Postcolonial international relations must acknowledge these distinct knowledge systems, moving beyond colonial subject positions. Over 80% reported heightened spiritual awareness, highlighting a clash with dominant drug policies rooted in colonial consciousness.

Abstract

This is the final version. Available on open access from Taylor & Francis via the DOI in this record

The neuroscientific study of spiritual practices

Frontiers in Psychology  – March 18, 2014

Summary

The neurobiological correlates of spiritual practices are being unveiled through advanced neuroimaging. Functional magnetic resonance imaging (fMRI) and other techniques offer a unique perspective in Psychology, elucidating brain activity during diverse experiences, from meditation and mindfulness to mediumistic trance. This field, at the intersection of Religion, Spirituality, and Psychology, promises profound insights into consciousness by objectively measuring brain function during subjective spiritual phenomena. Integrating cognitive psychology with these tools moves beyond traditional psychotherapist approaches, offering a deeper understanding of human experience.

Abstract

The purpose of this paper will be to provide a perspective on the current state of the research evaluating the neurobiological correlates of spirit...

Dose-response relationships of LSD-induced subjective experiences in humans

OpenAlex  – November 07, 2022

Summary

Lysergic acid diethylamide (LSD), a potent hallucinogen, profoundly alters consciousness, with effects largely plateauing around 100 μg. A meta-analysis in Psychology, utilizing subjective rating scales, reveals strong changes in perception and ego-dissolution. Crucially, minimal effects on Anxiety were observed. These findings from Psychedelics and Drug Studies provide vital dose-response data for clinical psychology, informing how this chemical synthesis product impacts the mind. Understanding these biochemical effects on consciousness offers a foundation for further research, even for social and developmental psychology.

Abstract

Abstract Lysergic acid diethylamide (LSD) is a potent classic serotonergic psychedelic, which facilitates a variety of altered states of consciousn...

Psychedelics: a window into perceptual processing

OpenAlex  – September 13, 2024

Summary

Psilocybin-induced visual distortions and impaired executive function originate in temporary disruptions of attentional mechanisms, a key finding for cognitive psychology. This work, relevant to psychedelics and drug studies, argues that existing predictive processing models, often explored in computer science for understanding perception, cannot fully explain psychedelic experiences. Instead, a new "Gist Theory of Perception" is proposed. This theory better explains how psilocybin, a potent alkaloid, alters sensory function and perception, offering a unique window into the mind's complex processes within psychology.

Abstract

Abstract This chapter presents findings indicating that psilocybin-induced visual distortions and impaired executive functioning originate in tempo...